IncrementsComboCartesian

IncrementsComboCartesian is the class for increments control in combination trials where separate increment rules are defined for each drug and applied independently.

Usage

IncrementsComboCartesian(drug1, drug2)

.DefaultIncrementsComboCartesian()

Arguments

drug1

(Increments) see slot definition.

drug2

(Increments) see slot definition.

Details

Under this rule, the maximum admissible dose for each drug is first computed from the corresponding one-dimensional increment rule. The resulting two-dimensional admissible region is then represented in a matrix form compatible with combination maxDose methods.

Slots

drug1

(Increments) increment rule for the first drug.

drug2

(Increments) increment rule for the second drug.

Note

Typically, end users will not use the .DefaultIncrementsComboCartesian() function.

Examples

# Create independent increment rules for each drug in a two-drug combination
# trial.
drug1_rule <- IncrementsRelative(intervals = c(0, 20), increments = c(1, 0.33))
drug2_rule <- IncrementsRelative(intervals = c(0, 20), increments = c(1, 0.33))

# Combine the one-dimensional rules into a Cartesian combination rule.
my_increments <- IncrementsComboCartesian(
  drug1 = drug1_rule,
  drug2 = drug2_rule
)