IncrementsComboOneDrugOnly

IncrementsComboOneDrugOnly is the class for increments control in combination trials when only one drug is allowed to be escalated.

Usage

IncrementsComboOneDrugOnly()

.DefaultIncrementsComboOneDrugOnly()

Details

Under this rule, when escalating drug 1 to a dose above the last administered drug 1 dose, drug 2 must remain at or below its last administered dose, and vice versa. In other words, at most one drug may be escalated in any given cohort. No parameters are required; the rule is fully defined by the "one drug only" principle.

Note

Typically, end users will not use the .DefaultIncrementsComboOneDrugOnly() function.

Examples

# Create a rule that allows escalation of only one drug at a time in a
# two-drug combination trial.
my_increments <- IncrementsComboOneDrugOnly()