Simulations — Simulations-class • crmPack

This class captures the trial simulations from model based designs. Additional slots fit, stop_reasons, stop_report, additional_stats, and overdose_prob compared to the general class GeneralSimulations.

Usage

Simulations(
  fit,
  stop_reasons,
  stop_report,
  additional_stats,
  ...,
  overdose_prob = NULL
)

.DefaultSimulations()

Arguments

fit: (list)
see slot definition.
stop_reasons: (list)
see slot definition.
stop_report: see Simulations
additional_stats: (list)
see slot definition.
...: additional parameters from GeneralSimulations
overdose_prob: (numeric)
see slot definition. If omitted, it is initialized to NA for backwards compatibility.

Slots

fit: (list)
final fits
stop_reasons: (list)
stopping reasons for each simulation run
stop_report: matrix of stopping rule outcomes
additional_stats: list of additional statistical summary
overdose_prob: (numeric)
posterior probability that the toxicity probability at the final recommended dose exceeds the upper target bound, for each simulation run. This is NA when no dose is recommended.

Note

Typically, end users will not use the .DefaultSimulations() function.

Examples

data <- list(
  Data(
    x = 1:2,
    y = 0:1,
    doseGrid = 1:2,
    ID = 1L:2L,
    cohort = 1L:2L
  ),
  Data(
    x = 3:4,
    y = 0:1,
    doseGrid = 3:4,
    ID = 1L:2L,
    cohort = 1L:2L
  )
)

doses <- c(1, 2)

seed <- as.integer(123)

fit <- list(
  c(0.1, 0.2),
  c(0.3, 0.4)
)

stop_report <- matrix(c(TRUE, FALSE), nrow = 2)

stop_reasons <- list("A", "B")

additional_stats <- list(a = 1, b = 1)

simulations <- Simulations(
  fit = fit,
  stop_report = stop_report,
  stop_reasons = stop_reasons,
  additional_stats = additional_stats,
  data,
  doses,
  seed
)